Alessio Nocentini Selected Research

Benzenesulfonamides

1/2022	Novel benzenesulfonamide-bearing pyrazoles and 1,2,4-thiadiazoles as selective carbonic anhydrase inhibitors.
5/2020	Hypoxia-Activated Prodrug Derivatives of Carbonic Anhydrase Inhibitors in Benzenesulfonamide Series: Synthesis and Biological Evaluation.
1/2020	Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action.
1/2020	Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy.
1/2020	Appliance of the piperidinyl-hydrazidoureido linker to benzenesulfonamide compounds: Synthesis, in vitro and in silico evaluation of potent carbonic anhydrase II, IX and XII inhibitors.
12/2019	Continued exploration and tail approach synthesis of benzenesulfonamides containing triazole and dual triazole moieties as carbonic anhydrase I, II, IV and IX inhibitors.
11/2019	Highly hydrophilic 1,3-oxazol-5-yl benzenesulfonamide inhibitors of carbonic anhydrase II for reduction of glaucoma-related intraocular pressure.
5/2019	Novel Diamide-Based Benzenesulfonamides as Selective Carbonic Anhydrase IX Inhibitors Endowed with Antitumor Activity: Synthesis, Biological Evaluation and In Silico Insights.
4/2019	Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines.
1/2019	Design, synthesis, and carbonic anhydrase inhibition activity of benzenesulfonamide-linked novel pyrazoline derivatives.

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Alessio Nocentini Research Topics

Disease

73	Neoplasms (Cancer) 12/2022 - 11/2015
17	Glaucoma 12/2022 - 12/2016
7	Hypoxia (Hypoxemia) 12/2022 - 10/2018
6	Breast Neoplasms (Breast Cancer) 12/2022 - 10/2017
5	Epilepsy (Aura) 01/2022 - 07/2017
5	Dandruff 01/2018 - 01/2016
4	Neuralgia (Stump Neuralgia) 12/2021 - 01/2017
3	Arthritis (Polyarthritis) 12/2020 - 01/2018
2	Malaria 12/2022 - 12/2020
2	Pancreatic Neoplasms (Pancreatic Cancer) 12/2022 - 11/2017
2	Acidosis 12/2022 - 05/2020
2	Rheumatoid Arthritis 12/2020 - 01/2019
2	Leishmaniasis 12/2019 - 04/2019
2	Chagas Disease (American Trypanosomiasis) 12/2019 - 04/2019
2	Retinitis Pigmentosa (Pigmentary Retinopathy) 12/2019 - 01/2018
2	Colorectal Neoplasms (Colorectal Cancer) 12/2018 - 10/2017
1	Glioblastoma (Glioblastoma Multiforme) 12/2022
1	Edema (Dropsy) 01/2022
1	Altitude Sickness (Mountain Sickness) 01/2022
1	Cognitive Dysfunction 12/2021
1	Acquired Immunodeficiency Syndrome (AIDS) 12/2021
1	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 12/2021
1	Phobic Disorders (Phobia) 12/2021
1	Central Nervous System Diseases (CNS Diseases) 12/2021
1	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive) 12/2021
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 10/2021
1	Urinary Bladder Neoplasms (Bladder Cancer) 10/2021
1	Brain Ischemia (Cerebral Ischemia) 05/2021
1	COVID-19 04/2021
1	Infections 04/2021
1	Visceral Pain 01/2021
1	Colitis 01/2021
1	Pain (Aches) 12/2020
1	Pigmentation Disorders (Ito Syndrome) 12/2020

Drug/Important Bio-Agent (IBA)

64	Protein Isoforms (Isoforms)IBA 12/2022 - 11/2015
52	Carbonic Anhydrases (Carbonic Anhydrase)IBA 12/2022 - 11/2015
27	SulfonamidesIBA 01/2022 - 11/2015
17	Pharmaceutical PreparationsIBA 06/2022 - 01/2017
14	Carbonic Anhydrase InhibitorsIBA 12/2022 - 10/2017
13	BenzenesulfonamidesIBA 01/2022 - 05/2018
12	EnzymesIBA 12/2022 - 01/2016
10	Carbonic Anhydrase IXIBA 12/2022 - 12/2016
10	CoumarinsIBA 12/2022 - 11/2015
6	SLC-0111IBA 12/2022 - 12/2018
6	IsoenzymesIBA 12/2022 - 12/2017
5	Acetazolamide (Diamox)FDA LinkGeneric 12/2022 - 01/2017
4	ProdrugsIBA 06/2022 - 12/2018
4	ZincIBA 01/2020 - 10/2018
3	Carboxylic AcidsIBA 01/2022 - 05/2020
3	coumarinIBA 01/2022 - 03/2020
3	Biological ProductsIBA 05/2020 - 01/2019
2	Proteins (Proteins, Gene)FDA Link 12/2022 - 10/2018
2	Sulfonic AcidsIBA 12/2021 - 01/2021
2	BenzopyransIBA 12/2021 - 10/2021
2	CaspasesIBA 12/2021 - 10/2021
2	OximesIBA 12/2021 - 10/2018
2	benzofuranIBA 04/2021 - 05/2020
2	dorzolamide (Trusopt)FDA LinkGeneric 01/2020 - 01/2018
2	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2020 - 11/2017
2	Adrenergic Agents (Adrenergic Drugs)IBA 10/2019 - 01/2018
2	Celecoxib (Celebrex)FDA Link 01/2018 - 01/2017
2	CosmeticsIBA 01/2017 - 01/2016
1	ChalconesIBA 12/2022
1	boric acid (boron oxide hydroxide)IBA 12/2022
1	Oxygen (Dioxygen)IBA 01/2022
1	Sulfanilamide FDA Link 01/2022
1	pyrazoleIBA 01/2022
1	KetonesIBA 01/2022
1	Steryl-Sulfatase (Steroid Sulfatase)IBA 01/2022
1	Angiogenesis InhibitorsIBA 01/2022
1	piperineIBA 12/2021
1	Histamine AgonistsIBA 12/2021
1	elsulfavirineIBA 12/2021
1	Reverse Transcriptase InhibitorsIBA 12/2021
1	NucleosidesIBA 12/2021
1	Ether (Diethyl Ether)IBA 12/2021
1	Caspase 3 (Caspase-3)IBA 10/2021
1	quinolineIBA 10/2021
1	Monoclonal AntibodiesIBA 10/2021
1	quemliclustatIBA 10/2021
1	SulfonesIBA 06/2021
1	Protective AgentsIBA 05/2021
1	Tissue Plasminogen Activator (Alteplase)FDA Link 05/2021
1	Antiviral Agents (Antivirals)IBA 04/2021
1	Peptide Hydrolases (Proteases)FDA Link 04/2021
1	Carbonic Anhydrase IVIBA 01/2021
1	2,4-dinitrofluorobenzene sulfonic acidIBA 01/2021
1	AmidesIBA 12/2020
1	AcetylcholinesteraseIBA 12/2020
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 12/2020
1	Anti-Bacterial Agents (Antibiotics)IBA 12/2020
1	Benzofurans (Coumarones)IBA 12/2020
1	ButyrylcholinesteraseIBA 12/2020
1	FuraginIBA 12/2020
1	Schiff Bases (Schiff Base)IBA 12/2020
1	Monophenol Monooxygenase (Tyrosinase)IBA 12/2020
1	Molecular Probes (Molecular Probe)IBA 12/2020

Therapy/Procedure

9	Therapeutics 12/2022 - 01/2017
2	Radiotherapy 12/2022 - 05/2020
1	Immunotherapy 10/2021